John C Kim and International Adoption Video

Wednesday, September 22, 2010

Fwd: Probiotics and colic Lactobacillus reuteri DSM 17938 in Infantile Colic: A Randomized, Double-Blind, Placebo-Controlled Trial -- Savino et al. 126 (3): e526 -- Pediatrics

 

From Evernote:

Lactobacillus reuteri DSM 17938 in Infantile Colic: A Randomized, Double-Blind, Placebo-Controlled Trial -- Savino et al. 126 (3): e526 -- Pediatrics

Clipped from: http://pediatrics.aappublications.org/cgi/content/abstract/126/3/e526
DOes anyone know where to get this stuff? 
Published online August 16, 2010
PEDIATRICS Vol. 126 No. 3 September 2010, pp. e526-e533 (doi:10.1542/peds.2010-0433)
This Article
Right arrow Full Text  to you
Right arrow Full Text (PDF)  to you
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Google Scholar
Right arrow Articles by Savino, F.
Right arrow Articles by Matteuzzi, D.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Savino, F.
Right arrow Articles by Matteuzzi, D.
Related Collections
Right arrow Nutrition & Metabolism 
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter   
What's this?

ARTICLES

Lactobacillus reuteri DSM 17938 in Infantile Colic: A Randomized, Double-Blind, Placebo-Controlled Trial

Francesco Savino, MD, PhDa, Lisa Cordisco, PhDb,Valentina Tarasco, MDa, Elisabetta Palumeri, MDa,Roberto Calabrese, BSca, Roberto Oggero, MDa,Stefan Roos, PhDc, Diego Matteuzzi, PhDb

a Department of Pediatrics, Regina Margherita Children Hospital, University of Turin, Turin, Italy; 
b Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy; and 
c Department of Microbiology, Swedish University of Agricultural Sciences, Uppsala, Sweden

OBJECTIVE To test the efficacy of Lactobacillus reuteri on infantile colic and to evaluate its relationship to the gut microbiota.

STUDY DESIGN Fifty exclusively breastfed colicky infants, diagnosed according to modified Wessel's criteria, were randomly assigned to receive either L reuteri DSM 17 938 (108 colony-forming units) or placebo daily for 21 days. Parental questionnaires monitored daily crying time and adverse effects. Stool samples were collected for microbiologic analysis.

RESULTS Forty-six infants (L reuteri group: 25; placebo group: 21) completed the trial. Daily crying times in minutes/day (median [interquartile range]) were 370 (120) vs 300 (150) (P = .127) on day 0 and 35.0 (85) vs 90.0 (148) (P = .022) on day 21, in the L reuteri and placebo groups, respectively. Responders (50% reduction in crying time from baseline) were significantly higher in the L reuteri group versus placebo group on days 7 (20 vs 8; P = .006), 14 (24 vs 13; P = .007), and 21 (24 vs 15; P = .036). During the study, there was a significant increase in fecal lactobacilli (P = .002) and a reduction in fecal Escherichia coli and ammonia in the L reuteri group only (P = .001). There were no differences in weight gain, stooling frequency, or incidence of constipation or regurgitation between groups, and no adverse events related to the supplementation were observed.

CONCLUSION L. reuteri DSM 17 938 at a dose of 108 colony-forming units per day in early breastfed infants improved symptoms of infantile colic and was well tolerated and safe. Gut microbiota changes induced by the probiotic could be involved in the observed clinical improvement.


Key Words: Lactobacillus reuteri • infantile colic • FISH • gut microflora • Escherichia coli


No comments:

Personal Web site for John C Kim: KIDDOC.ORG

I am a pediatrician specializing in General Pediatrics, International Adoption Medicine, and in the diagnosis and coaching of families pursuing joy.