RE: Probiotics and colic Lactobacillus reuteri DSM 17938 in Infantile Colic: A Randomized, Double-Blind, Placebo-Controlled Trial -- Savino et al. 126 (3): e526 -- Pediatrics

Ok, I've been wondering the same thing, so I went interneting : Sold as Biogaia

Not sold at Vitamin Cottage.

Walgreens will order and ship free through their online site within 2 days - Biogaia, $35.50 for 1 one month supply.

Can also be ordered over the internet from Everidis at about the same price, but then $7.00 for shipping.

I couldn't find any other sources in town, but did not check every store.

Karen

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From: John Kim [mailto:jkim@kiddoc.org]
Sent: Wednesday, September 22, 2010 9:37 PM
To: kiddoc blogger; Arlene Roman Kim; David Bertoncini; Drew Jun; Jimmy Ching; Karen Childs Colorado.Mountain View Pediatrics; Summer Scheid; Susan Lim; Yuri WU
Subject: Fwd: Probiotics and colic Lactobacillus reuteri DSM 17938 in Infantile Colic: A Randomized, Double-Blind, Placebo-Controlled Trial -- Savino et al. 126 (3): e526 -- Pediatrics

From Evernote:

Lactobacillus reuteri DSM 17938 in Infantile Colic: A Randomized, Double-Blind, Placebo-Controlled Trial -- Savino et al. 126 (3): e526 -- Pediatrics Clipped from: http://pediatrics.aappublications.org/cgi/content/abstract/126/3/e526

DOes anyone know where to get this stuff? 

Published online August 16, 2010
PEDIATRICS Vol. 126 No. 3 September 2010, pp. e526-e533 (doi:10.1542/peds.2010-0433)

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ARTICLES

Lactobacillus reuteri DSM 17938 in Infantile Colic: A Randomized, Double-Blind, Placebo-Controlled Trial

Francesco Savino, MD, PhD^a, Lisa Cordisco, PhD^b,Valentina Tarasco, MD^a, Elisabetta Palumeri, MD^a,Roberto Calabrese, BSc^a, Roberto Oggero, MD^a,Stefan Roos, PhD^c, Diego Matteuzzi, PhD^b

^a Department of Pediatrics, Regina Margherita Children Hospital, University of Turin, Turin, Italy; 
^b Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy; and 
^c Department of Microbiology, Swedish University of Agricultural Sciences, Uppsala, Sweden

OBJECTIVE To test the efficacy of Lactobacillus reuteri on infantile colic and to evaluate its relationship to the gut microbiota.

STUDY DESIGN Fifty exclusively breastfed colicky infants, diagnosed according to modified Wessel's criteria, were randomly assigned to receive either L reuteri DSM 17 938 (10⁸ colony-forming units) or placebo daily for 21 days. Parental questionnaires monitored daily crying time and adverse effects. Stool samples were collected for microbiologic analysis.

RESULTS Forty-six infants (L reuteri group: 25; placebo group: 21) completed the trial. Daily crying times in minutes/day (median [interquartile range]) were 370 (120) vs 300 (150) (P = .127) on day 0 and 35.0 (85) vs 90.0 (148) (P = .022) on day 21, in the L reuteri and placebo groups, respectively. Responders (50% reduction in crying time from baseline) were significantly higher in the L reuteri group versus placebo group on days 7 (20 vs 8; P = .006), 14 (24 vs 13; P = .007), and 21 (24 vs 15; P = .036). During the study, there was a significant increase in fecal lactobacilli (P = .002) and a reduction in fecal Escherichia coli and ammonia in the L reuteri group only (P = .001). There were no differences in weight gain, stooling frequency, or incidence of constipation or regurgitation between groups, and no adverse events related to the supplementation were observed.

CONCLUSION L. reuteri DSM 17 938 at a dose of 10⁸ colony-forming units per day in early breastfed infants improved symptoms of infantile colic and was well tolerated and safe. Gut microbiota changes induced by the probiotic could be involved in the observed clinical improvement.

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Key Words: Lactobacillus reuteri • infantile colic • FISH • gut microflora • Escherichia coli

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