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Prevalence of Colonization not causing disease in young well children is 12% Prevalence of Streptococcal Pharyngitis and Streptococcal Carriage in Children: A Meta-analysis -- Shaikh et al. 126 (3): e557 -- Pediatrics

 


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Prevalence of Colonization not causing disease in young well children is 12% Prevalence of Streptococcal Pharyngitis and Streptococcal Carriage in Children: A Meta-analysis -- Shaikh et al. 126 (3): e557 -- Pediatrics

Clipped from: http://pediatrics.aappublications.org/cgi/content/abstract/126/3/e557
Published online August 9, 2010
PEDIATRICS Vol. 126 No. 3 September 2010, pp. e557-e564 (doi:10.1542/peds.2009-2648)
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ARTICLES

Prevalence of Streptococcal Pharyngitis and Streptococcal Carriage in Children: A Meta-analysis

Nader Shaikh, MD, MPHa, Erica Leonard, MDb,Judith M. Martin, MDc

Divisions of a General Academic Pediatrics and 
c Pediatric Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and 
b Swedish Family Medicine Residency Program, Seattle, Washington

OBJECTIVES Prevalence estimates can help clinicians make informed decisions regarding diagnostic testing of children who present with symptoms of pharyngitis. We conducted a meta-analysis to determine the (1) prevalence of streptococcal infection among children who presented with sore throat and (2) prevalence of streptococcal carriage among asymptomatic children.

METHODS We searched Medline for articles on pediatric streptococcal pharyngitis. We included articles in our review when they contained data on the prevalence of group A Streptococcus (GAS) from pharyngeal specimens in children who were younger than 18 years. Two evaluators independently reviewed, rated, and abstracted data from each article. Prevalence estimates were pooled in a meta-analysisand stratified according to age group.

RESULTS Of the 266 articles retrieved, 29 met all inclusion criteria. Among children of all ages who present with sore throat, the pooled prevalence of GAS was 37% (95% confidence interval [CI]: 32%–43%). Children who were younger than 5 years had a lower prevalence of GAS (24% [95% CI: 21%–26%]). The prevalence of GAS carriage among well children with no signs or symptoms of pharyngitis was 12% (95% CI: 9%–14%).

CONCLUSIONS Prevalence rates of GAS disease and carriage varied by age; children who were younger than 5 years had lower rates of throat cultures that were positive for GAS.

Key Words: Streptococcus • carriage • pediatrics • prevalence • meta-analysis

Abbreviations: GAS = group A Streptococcus • CI = confidence interval

Accepted May 20, 2010.

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I am a pediatrician specializing in General Pediatrics, International Adoption Medicine, and in the diagnosis and coaching of families pursuing joy.